The protein structure prediction problem continues to elude scientists. Any opinions, findings, and conclusions or recommendations expressed in this material are those of the authors and do not necessarily reflect the views of the national science foundation. Saudi arabian group, leading building materials and investment group headquartered in khobar ksa. He is syrias alltime record goalscorer with 36 goals. Online gamers solve 10yearold science problem in 10 days. Despite the introduction of many methods, only modest gains were made over the last decade for certain classes of prediction ta. Foldit playerss research works carnegie mellon university, pa. It looks like we dont have any biography for firas al khatib yet be the first to contribute. Firas khatib, frank dimaio, foldit contenders group, foldit void crushers group, seth cooper, maciej kazmierczyk, miroslaw gilski, szymon krzywda, helena zabranska, iva pichova, james thompson, zoran popovic, mariusz jaskolski and david baker. Online gamers help solve protein structure scientific. Foldit players interact with protein structures using direct manipulation tools and userfriendly versions of algorithms from the. It is part of an experimental research project developed by the university of washington, center for game science, in collaboration with the uw department of biochemistry. Curriculum vitae general information boston university.
The ability to design a new protein fold makes possible the exploration of the large regions of the protein universe. Algorithm discovery by protein folding game players. It is implemented in crossplatform cand binary executables are available for windows, macos and linux. Oct 08, 2011 online gamers help solve mystery of critical aids virus enzyme.
Predicting protein structures with a multiplayer online game. In contrast to most commandline or batch interactions with rosetta, foldit standalone is designed to allow easy, realtime, direct manipulation of protein structures, while also giving access to the extensive power of rosetta computations. Media in category firas alkhatib the following 5 files are in this category, out of 5 total. Pdf wefold paper final rodrigo faccioli, silvia crivelli. Tyka, kefan xu, ilya makedon, zoran popovic, david baker and foldit players. See the complete profile on linkedin and discover firas. Nov 22, 2011 foldit is a multiplayer online game in which players collaborate and compete to create accurate protein structure models. Get season stats, career statistics, game logs and injury updates on the syria none. Proceedings of the national academy of sciences of the united states of america 2011. Crystal structure of a monomeric retroviral protease.
This is one small piece of the puzzle in being able to help with aids, firas khatib, a biochemist at the university of washington, the institution which invented the game, told msnbc. Returning veteran firas al khatib, an exfavourite of shanghai shenhua, could hold key for syria against australia in tuesdays world cup playoff. However, very little is known about how collaborative gameplay produces these results and whether foldit player strategies can be formalized and. Citation if you use foldit standalone in your work, please cite. Algorithm discovery by protein folding game players pnas. The university of washington are investigating whether the brainpower of humans. Firas khatib, ambroise desfosses, foldit players, brian koepnick, jeff flatten, zoran popovic, david baker, seth cooper, irina gutsche, scott horowitz. Also, a protein can fold up into so many possible shapes that a. Seth cooper, firas khatib, ilya makedon, hao lu, janos barbero, david baker, james fogarty, zoran popovic and foldit players. Returning veteran firas alkhatib, an exfavourite of shanghai shenhua, could hold key for syria against australia in tuesdays world cup playoff. Foldit players were able to sample closer to the native fold by rebuilding several incorrect loops fig. Online gamers help solve mystery of critical aids virus enzyme.
Foldit standalone is available for download at, under the rosetta license, which is. Oct 02, 2011 when scientists fail, call in the gamers for more than a decade, researchers were stumped by the structure of a tiny protein that causes aids in rhesus monkeys. The university of washington are investigating whether the brainpower of humans worldwide can be. According to firas khatib, a researcher at the university of washingtons. The michaelis constants, k mdiene and k mdienophile table 1, of ce6 are improved 6 fold and 3 fold respectively compared to the starting design, but the turnover number k cat is unchanged. Just click the edit page button at the bottom of the page or learn more in the biography submission guide. Researchers created the game foldit to simulate protein folding and used teams of online gamers to help solve the structure of an enzyme. For specific hard problems, foldit player solutions can in some cases outperform stateoftheart computational methods. Analysis of social gameplay macros in the foldit cookbook. Sep 19, 2011 this is one small piece of the puzzle in being able to help with aids, firas khatib, a biochemist at the university of washington, the institution which invented the game, told msnbc.
Siegel7,8,9, firas khatib10 and seth cooper1, 1college of computer and information science, northeastern university, boston, ma 02115, usa, 2department of. Thesis university of illinois at urbanachampaign elkhatib, f. Foldit standalone is an interactive graphical interface to the rosetta molecular modeling package. Insiders say todd phillips never pitched origin film series on other dc characters. Robert kleffner, jeff flatten, andrew leaverfay, david baker, justin b. Join facebook to connect with firas al khatib and others you may know. Now close to 200,000 registered players around the world are playing foldit. Select the foldit standalone download link for your platform. The improvement in k m but lack of change in k cat are consistent with the design model and crystal structure. Fold xx is a new fold, previously unobserved in natural proteins. Firas elkhatib, phd, gives us a short introduction to himself and then explains some of his work developing the bionic pancreas focusing especially on the challenges of developing an algorithm.
Oct 31, 2009 the university of washington are investigating whether the brainpower of humans worldwide can be. Foldit playerss 9 research works with 229 citations and 1521 reads, including. Join facebook to connect with firas khatib and others you may know. Science editors choice highresolution structure of a retroviral protease folded as a monomer. Foldit is an online puzzle video game about protein folding. Darpa, nsf, nih, hhmi, microsoft, adobe, and rosettacommons this material is based upon work supported by the national science foundation under grant no. Crystal structure of a monomeric retroviral protease solved by protein folding game players. Patents, intellectual property, and provisional disclosures. Pdf algorithm discovery by protein folding game players. Pdf crystal structure of a monomeric retroviral protease. Solving puzzles for science life sciences research weekend 2010. Online gamers help solve protein structure scientific american.
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